Companies · Pharmaceuticals

VYNE Therapeutics Inc.

BRIDGEWATER · Pharmaceuticals

Diligence memoA one-page analyst read on VYNE Therapeutics Inc. — recommendation, valuation, rhythm, risks.
$139.5M
Total raised · real
4
Rounds
293.8×
Latest step-up
Top 7%
Sector rank · raised
Series C
Latest stage · inferred · Wed Nov 01 2023 00:00:00 GMT+0000 (Coordinated Universal Time)

VYNE Therapeutics Inc. looks over-valued against its niche peers and is at-risk on financing cadence.

Synthesized from the figures below est. — every claim rests on a number shown on this page. Valuation uses the pharma sector profile.

Analyst read est. — computed against this company's niche peers in the same era. Inputs shown; not a quoted figure.

Over-valued
  • Modeled value is 1.69× the median modeled value of Series C Pharmaceuticals companies in 2022–2024 (30 peers) — value vs value, same stage and era.
At-risk
  • Last raise 2.7 yr ago; this sector typically re-raises about every 13 months.
  • Past due for a raise versus sector cadence — watch for distress or a bridge.
Leadership

No named principal in this company's public records yet — see all operators below.

Explore how these operators interlock with other companies in the operator network.

Where it sits in Pharmaceuticals

VYNE Therapeutics Inc. is one of 1613 Pharmaceuticals companies tracked from BRIDGEWATER. By capital raised it ranks among the largest (ahead of 94% of sector peers), and in the upper tier by modeled valuation est..

Ranking is computed against this company's own sector cohort — reported capital is fact; valuation tiers are modeled.

pharma

As reported in public records reported — not modeled.

US
Jurisdiction
Rule 506(b)
Reg D exemption
19
Investors (latest)
2023-11-01
First sale
Amount raised vs valuation, by round

Solid bars are reported offering amounts reported; hatched bars are the modeled post-money valuation est. — both on one shared scale so you can read raise-vs-worth at each round directly. Use the toggles to overlay data labels and the niche-peer / market average value lines.

Amount raised · realModeled valuation · estCumulative funded · real
$0$500M$1.0B$1.5B$2.0BPre-Seed · 2012-12-21 Raised $500K (real) Modeled valuation $24M (est)$500K$24MPre-Seed2012Series C · 2017-07-14 Raised $51M (real) Modeled valuation $1.8B (est)$51M$1.8BSeries C2017Series C · 2022-11-14 Raised $300K (real) Modeled valuation $4.6M (est)$300K$4.6MSeries C2022Series C · 2023-11-01 Raised $88M (real) Modeled valuation $972M (est)$88M$972MSeries C2023+$51M+$300K+$88MCumulative $139M

The line shows cumulative reported funding over the period; + labels show new capital added between points when there is room. Toggle on-bar figures, plus the niche-peer and market averages, to read this company against its cohort. Benchmarks are modeled medians.

Financing ladder & sequence gaps
Pre-Seed$500K · 2012
Series C$50.5M · 2017no Seed / Series A / Series B on file
Series C extension$300K · 2022
Series C extension$88.2M · 2023

Stages are modeled from round size (public records carry no series label). No record for: Seed, Series A, Series B — the company may have raised it under a different exemption, merged it into an adjacent record, or skipped it. Sequence completeness: 40%.

Modeled valuation trajectory
$972.1M
Base estimate est.
$286.3M
Conservative case
$1.6B
Upside case
$587.7M
Modeled post-money

Round size and date are reported; the stage label is inferred from round size (latest is Series Ca $40M–$100M round). Valuation is modeled from stage benchmarks scaled by the pharma sector profile. Directional, not a quoted figure.

Pre-Seed · modeled $23.7M · 2012-12-212012Series C · modeled $1.8B · 2017-07-14Series C · modeled $4.6M · 2022-11-14Series C · modeled $972.1M · 2023-11-012023
Model inputs · modeled:benchmark-stage-stepup-v1
15%
Dilution assumption
Implied ownership sold in the financing.
66%
Survival probability
49% low · 76% high
1.42×/yr
Annual markup
1.62×/yr upside case
2.7 yr
Elapsed time used
2.7 yr actual, capped for stale marks
pharma
Sector profile
Adjusts growth and survival by industry.
Financing rhythm
43 mo
Avg between rounds
$12.8M/yr
Capital velocity
13.5 yr
On record since
2012
First round
4
Rounds on file
How it compares to the market

Benchmarked against 1613 companies in Pharmaceuticals. Each bar is a median (the middle company, not an average — outliers don't skew it). Two yardsticks: real money raised (reported on Form D) and modeled value (our estimate est.). These are whole-sector medians across all stages, except the per-stage row.

Total raised — vs sector median (real $, all stages) 17× above median
This company$139.5M
Sector median$8.1M
Latest round — vs other Series C rounds in sector (real $, this stage) 1.9× above median
This company$88.2M
Sector median$46.4M
Modeled value — vs sector median (estimate, all stages) 13× above median
This company$972.1M
Sector median$76.1M

Raised more than 94% of sector peers (real $). Modeled value above 88% of peers (estimate).

Niche peers — same stage & era

A tighter cohort than the sector chart above — only companies at the same stage (Series C) that last raised in the same ~3-year era, ranked by modeled value est. (not money raised). This is the exact set the analyst read compares against, so a like-for-like cohort is what makes "over/under-valued" meaningful. This company ranks #4 of 30.

This companyCohort peer
$100.0M$1.0B$10.0B$10.0M$100.0M$1.0BCapital raised (log)Vigil Neuroscience, Inc. · Series C Raised $215.0M · modeled $1.3B (est)Leap Therapeutics, Inc. · Series C Raised $105.1M · modeled $1.1B (est)Alimera Sciences Inc · Series C Raised $173.8M · modeled $1.1B (est)Lusaris Therapeutics, Inc. · Series C Raised $60.2M · modeled $955.7M (est)Context Therapeutics Inc. · Series C Raised $100.0M · modeled $923.0M (est)Enliven Therapeutics, Inc. · Series C Raised $140.1M · modeled $867.9M (est)Tenax Therapeutics, Inc. · Series C Raised $138.4M · modeled $841.5M (est)Faraday Pharmaceuticals, Inc. · Series C Raised $115.5M · modeled $830.5M (est)OnKure, Inc. · Series C Raised $123.2M · modeled $732.5M (est)Mind Medicine (MindMed) Inc. · Series C Raised $83.2M · modeled $730.2M (est)MBX Biosciences, Inc. · Series C Raised $74.8M · modeled $724.1M (est)VYNE Therapeutics Inc. (this company) Raised $139.5M · modeled $972.1M (est)VYNE Therapeutics Inc.
CompanyStageRaised · realValue · estvs peer med.
Vigil Neuroscience, Inc.Series C$215.0M$1.3B2.19×
Leap Therapeutics, Inc.Series C$105.1M$1.1B1.94×
Alimera Sciences IncSeries C$173.8M$1.1B1.91×
VYNE Therapeutics Inc. this companySeries C$139.5M$972.1M1.69×
Lusaris Therapeutics, Inc.Series C$60.2M$955.7M1.66×
Context Therapeutics Inc.Series C$100.0M$923.0M1.60×
Enliven Therapeutics, Inc.Series C$140.1M$867.9M1.51×
Tenax Therapeutics, Inc.Series C$138.4M$841.5M1.46×
Faraday Pharmaceuticals, Inc.Series C$115.5M$830.5M1.44×
OnKure, Inc.Series C$123.2M$732.5M1.27×
Mind Medicine (MindMed) Inc.Series C$83.2M$730.2M1.27×
MBX Biosciences, Inc.Series C$74.8M$724.1M1.26×
Full financing history

Stage is inferred from round size est., not reported on the filing — a round's dollar size maps to a bucket: Pre-Seed <$1.0M · Seed $1.0M–$4.0M · Series A $4.0M–$15M · Series B $15M–$40M · Series C $40M–$100M · Series D+ $100M–$400M · Growth/Late >$400M.

StageAmount · realAnnouncedPost-money · estValue · estConf.
Pre-Seed$500K2012-12-21$2.8M$23.7M85%
Series C$50.5M2017-07-14$336.7M$1.8B90%
Series C$300K2022-11-14$2.0M$4.6M90%
Series C$88.2M2023-11-01$587.7M$972.1M90%
What happened at each round

Step-up, pace versus the sector's normal cadence, and revenue/exemption moves — read straight from the reported round facts reported.

  1. Pre-Seed$500K2012-12-21
    • First recorded raise — entered as Pre-Seed.
    • 1 investor on this round.
  2. Series C$50.5M2017-07-14
    • Raised again after 55 mo — slower than the ~13 mo sector norm.
    • Round 101.0× larger than the prior — scaling up.
    • Switched to Rule 506(b) (was Rule 06).
    • 11 investors on this round.
  3. Series C$300K2022-11-14
    • Raised again after 64 mo — slower than the ~13 mo sector norm.
    • Round 168.3× smaller than the prior — bridge or down round.
    • 1 investor on this round.
  4. Series C$88.2M2023-11-01
    • Raised 12 mo later, in step with the ~13 mo sector norm.
    • Round 293.8× larger than the prior — scaling up.
    • 19 investors on this round.
Intelligence
2027 ~Q2
Modeled next raise · ~43mo cadence
$264.5M
Modeled next size est.range $171.9M$423.1M
293.8×
Last step-up
$12.8M/yr
Capital velocity

Predictive signals are modeled est. from this company's own cadence and step-up, plus sector benchmarks — directional, not advice. Peer set and a CSV export live in your analyst workspace.

Key people & operators

Officers, directors and promoters named in this company's public recordsreported — the people who run it (not its investors). "Also runs" counts come from name-matching across all records, so verify before acting.

PersonRoleAlso runsTied since
Andrew Perlman14 other2012-12
Anthony Bruno3 other2022-11
Edward Schnipper3 other2012-12
Steven Basta2 other2022-11
Albert L. Cha1 other2017-07
James Larrick1 other2012-12
Ketan L. Patel1 other2017-07
Steven L. Basta1 other2017-07
Aaron L. Royston2017-07
DAVID DOMZALSKI2022-11
David L. Collier2017-07
ELISABETH SANDOVAL2022-11
IAIN STUART2022-11
John L. Creecy2017-07
MUTYA HARSCH2022-11
PATRICK LEPORE2022-11
Scott L. Whitcup2017-07
SHARON BARBARI2022-11
Ted L. Ebel2017-07
TYLER ZERONDA2022-11
Registry & provenance

VYNE Therapeutics Inc. is an official record sourced from the U.S. Securities and Exchange Commission (SEC). U.S. data is aggregated from SEC Form D filings.

United States
Country of record
US
Jurisdiction
1566044
SEC CIK
Similar companies

Nearest neighbours across the whole database — matched on sector, stage and capital scale, and on shared operators (officers or directors named at both companies in public filings). A discovery shortlist, not a valuation cohort — verify before acting, the same way modeled figures are directional.

CompanySectorStageRaised · realValue · estWhy similar
Neos Therapeutics, Inc.PharmaceuticalsSeries B$163.6M$701.3Mnetwork1 shared operator · same sector
Enliven Therapeutics, Inc.PharmaceuticalsSeries C$140.1M$867.9Msame sector · same stage
Apellis Pharmaceuticals, Inc.PharmaceuticalsSeries C$140.2M$703.0Msame sector · same stage
Mirum Pharmaceuticals, Inc.PharmaceuticalsSeries C$138.5M$348.3Msame sector · same stage
Tenax Therapeutics, Inc.PharmaceuticalsSeries C$138.4M$841.5Msame sector · same stage
Carbylan Therapeutics, Inc.Other Health CareSeries A$15.0M$80.7Mnetwork3 shared operators
Arthrosi Therapeutics, Inc.PharmaceuticalsSeries C$132.9M$385.6Msame sector · same stage
Zogenix IncPharmaceuticalsSeries C$131.2M$526.4Msame sector · same stage
Semantically similar

Matched by meaning, not labels — a local language model reads each company's name, sector and description and ranks the closest in that learned space. This catches look-alikes that cross sector boundaries; the structured list above explains its matches, this one trusts the text. Directional, like every modeled signal here.

CompanySectorStageValue · estMatch
Dyne Therapeutics, Inc.BiotechnologySeries D+$4.6B86%
vTv Therapeutics Inc.PharmaceuticalsSeries C$502.3M83%
Vytalyx IncPharmaceuticalsSeries C$2.1B82%
Vyome Therapeutics Inc.PharmaceuticalsSeries A$351.1M82%
VST BIO CorpPharmaceuticalsSeries B$118.7M81%
Vivera Pharmaceuticals, Inc.PharmaceuticalsSeed$40.1M81%
Veana Therapeutics, Inc.PharmaceuticalsPre-Seed$32.9M81%
Orna Therapeutics Holdings, LLCBiotechnologySeries D+$2.5B80%
Frequently asked
How much funding has VYNE Therapeutics Inc. raised?
VYNE Therapeutics Inc. has raised approximately $139.5M in disclosed capital across 4 recorded financing rounds, aggregated from public filings.
What is VYNE Therapeutics Inc.'s estimated valuation?
Provath's modeled valuation for VYNE Therapeutics Inc. is approximately $972.1M (modeled range $286.3M–$1.6B). This is an algorithmic estimate derived from round sizes and same-niche peers — not a quoted or reported figure.
What funding stage is VYNE Therapeutics Inc. at?
VYNE Therapeutics Inc.'s latest modeled financing stage is Series C. Its most recent recorded round closed around Wed Nov 01.
What does VYNE Therapeutics Inc. do and where is it based?
VYNE Therapeutics Inc. operates in the Pharmaceuticals sector, based in BRIDGEWATER.
Explore related

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