Diligence memo · auto-generated · as of July 3, 2026
Karyopharm Therapeutics Inc.
Karyopharm Therapeutics Inc. looks fair against its niche peers and is at-risk on financing cadence.
Businessfiled
Karyopharm Therapeutics Inc. operates in Pharmaceuticals, based in NEWTON.
Sub-sector tags: pharma.
No verified homepage on file yet — operating evidence is limited to the public record.
Capital & rounds (filed)filed
Karyopharm Therapeutics Inc. has raised $205M in disclosed capital across 4 recorded rounds, aggregated from public filings. Its latest round is modeled as Series D+ (a $100M–$400M round).
Largest single filing: $165M on 2022-12-07.
Most recent recorded round closed around 2022-12-07.
Valuation (modeled)modeled
Provath models Karyopharm Therapeutics Inc. at approximately $2.8B (range $785M–$4.7B). This is an algorithmic estimate from round sizes and same-niche peers — not a quoted or reported figure.
Read: Fair. Modeled value is 1.48× the median modeled value of Series D+ Pharmaceuticals companies in 2022–2024 (18 peers) — value vs value, same stage and era. Within the normal band (148% of peer median) for its niche.
Financing rhythm & timingmixed
Historic cadence: a new round about every 49 months.
Last raise 3.6 yr ago; this sector typically re-raises about every 13 months.
Past due for a raise versus sector cadence — watch for distress or a bridge.
The last round stepped up 8.7× from the prior — scaling.
Comparablesmixed
Capital scale ranks ahead of 96% of Pharmaceuticals peers (1613 compared).
Modeled value ranks above 97% of those peers.
Closest niche peers: Paragon Biosciences Emalex Capital, Inc., TrialSpark, Inc., Fog Pharmaceuticals, Inc., MAPS Public Benefit Corp, ADARx Pharmaceuticals, Inc..
Peoplefiled
23 named people on file across officers, directors and signatories.
Risks & flagsmixed
Overdue for a raise versus sector norm — distress or bridge risk.
No clearly named CEO/founder/principal in the surfaced records — key-person evidence is thin.