Companies · Pharmaceuticals

Karyopharm Therapeutics Inc.

NEWTON · Pharmaceuticals

Diligence memoA one-page analyst read on Karyopharm Therapeutics Inc. — recommendation, valuation, rhythm, risks.
$205.2M
Total raised · real
4
Rounds
8.7×
Latest step-up
Top 5%
Sector rank · raised
Series D+
Latest stage · inferred · Wed Dec 07 2022 00:00:00 GMT+0000 (Coordinated Universal Time)

Karyopharm Therapeutics Inc. looks fair against its niche peers and is at-risk on financing cadence.

Synthesized from the figures below est. — every claim rests on a number shown on this page. Valuation uses the pharma sector profile.

Analyst read est. — computed against this company's niche peers in the same era. Inputs shown; not a quoted figure.

Fair
  • Modeled value is 1.48× the median modeled value of Series D+ Pharmaceuticals companies in 2022–2024 (18 peers) — value vs value, same stage and era.
  • Within the normal band (148% of peer median) for its niche.
At-risk
  • Last raise 3.6 yr ago; this sector typically re-raises about every 13 months.
  • Past due for a raise versus sector cadence — watch for distress or a bridge.
Leadership

No named principal in this company's public records yet — see all operators below.

Explore how these operators interlock with other companies in the operator network.

Where it sits in Pharmaceuticals

Karyopharm Therapeutics Inc. is one of 1613 Pharmaceuticals companies tracked from NEWTON. By capital raised it ranks among the largest (ahead of 96% of sector peers), and among the largest by modeled valuation est..

Ranking is computed against this company's own sector cohort — reported capital is fact; valuation tiers are modeled.

pharma

As reported in public records reported — not modeled.

US
Jurisdiction
Rule 506(b)
Reg D exemption
33
Investors (latest)
2022-12-07
First sale
Amount raised vs valuation, by round

Solid bars are reported offering amounts reported; hatched bars are the modeled post-money valuation est. — both on one shared scale so you can read raise-vs-worth at each round directly. Use the toggles to overlay data labels and the niche-peer / market average value lines.

Amount raised · realModeled valuation · estCumulative funded · real
$0$1.3B$2.5B$3.8B$5.0BPre-Seed · 2010-10-21 Raised $700K (real) Modeled valuation $33M (est)$700K$33MPre-Seed2010Series B · 2013-04-17 Raised $21M (real) Modeled valuation $697M (est)$21M$697MSeries B2013Series B · 2013-07-26 Raised $19M (real) Modeled valuation $646M (est)$19M$646MSeries B2013Series D+ · 2022-12-07 Raised $165M (real) Modeled valuation $2.8B (est)$165M$2.8BSeries D+2022+$21M+$19M+$165MCumulative $205M

The line shows cumulative reported funding over the period; + labels show new capital added between points when there is room. Toggle on-bar figures, plus the niche-peer and market averages, to read this company against its cohort. Benchmarks are modeled medians.

Financing ladder & sequence gaps
Pre-Seed$700K · 2010
Series B$20.5M · 2013no Seed / Series A on file
Series B extension$19.0M · 2013
Series D+$165.0M · 2022no Series C on file

Stages are modeled from round size (public records carry no series label). No record for: Seed, Series A, Series C — the company may have raised it under a different exemption, merged it into an adjacent record, or skipped it. Sequence completeness: 50%.

Modeled valuation trajectory
$2.8B
Base estimate est.
$785.4M
Conservative case
$4.7B
Upside case
$1.4B
Modeled post-money

Round size and date are reported; the stage label is inferred from round size (latest is Series D+a $100M–$400M round). Valuation is modeled from stage benchmarks scaled by the pharma sector profile. Directional, not a quoted figure.

Pre-Seed · modeled $33.1M · 2010-10-212010Series B · modeled $697.1M · 2013-04-17Series B · modeled $646.1M · 2013-07-26Series D+ · modeled $2.8B · 2022-12-072022
Model inputs · modeled:benchmark-stage-stepup-v1
12%
Dilution assumption
Implied ownership sold in the financing.
71%
Survival probability
57% low · 79% high
1.35×/yr
Annual markup
1.51×/yr upside case
3.6 yr
Elapsed time used
3.6 yr actual, capped for stale marks
pharma
Sector profile
Adjusts growth and survival by industry.
Financing rhythm
49 mo
Avg between rounds
$16.9M/yr
Capital velocity
15.7 yr
On record since
2010
First round
4
Rounds on file
How it compares to the market

Benchmarked against 1613 companies in Pharmaceuticals. Each bar is a median (the middle company, not an average — outliers don't skew it). Two yardsticks: real money raised (reported on Form D) and modeled value (our estimate est.). These are whole-sector medians across all stages, except the per-stage row.

Total raised — vs sector median (real $, all stages) 25× above median
This company$205.2M
Sector median$8.1M
Latest round — vs other Series D+ rounds in sector (real $, this stage) 1.5× above median
This company$165.0M
Sector median$111.8M
Modeled value — vs sector median (estimate, all stages) 37× above median
This company$2.8B
Sector median$76.1M

Raised more than 96% of sector peers (real $). Modeled value above 97% of peers (estimate).

Niche peers — same stage & era

A tighter cohort than the sector chart above — only companies at the same stage (Series D+) that last raised in the same ~3-year era, ranked by modeled value est. (not money raised). This is the exact set the analyst read compares against, so a like-for-like cohort is what makes "over/under-valued" meaningful. This company ranks #5 of 18.

This companyCohort peer
$1.0B$10.0B$100.0M$1.0BCapital raised (log)Paragon Biosciences Emalex Capital, Inc. · Series D+ Raised $376.8M · modeled $5.5B (est)TrialSpark, Inc. · Series D+ Raised $372.2M · modeled $4.1B (est)Fog Pharmaceuticals, Inc. · Series D+ Raised $278.4M · modeled $3.1B (est)MAPS Public Benefit Corp · Series D+ Raised $215.1M · modeled $2.9B (est)ADARx Pharmaceuticals, Inc. · Series D+ Raised $352.5M · modeled $2.8B (est)Olema Pharmaceuticals, Inc. · Series D+ Raised $527.4M · modeled $2.4B (est)Mineralys Therapeutics, Inc. · Series D+ Raised $118.0M · modeled $2.4B (est)Endo, Inc. · Series D+ Raised $170.6M · modeled $2.0B (est)TORL Biotherapeutics LLC · Series D+ Raised $158.3M · modeled $1.8B (est)UroGen Pharma Ltd. · Series D+ Raised $120.0M · modeled $1.7B (est)Renibus Therapeutics, Inc. · Series D+ Raised $180.1M · modeled $1.7B (est)Karyopharm Therapeutics Inc. (this company) Raised $205.2M · modeled $2.8B (est)Karyopharm Therapeutics Inc.
CompanyStageRaised · realValue · estvs peer med.
Paragon Biosciences Emalex Capital, Inc.Series D+$376.8M$5.5B2.85×
TrialSpark, Inc.Series D+$372.2M$4.1B2.17×
Fog Pharmaceuticals, Inc.Series D+$278.4M$3.1B1.62×
MAPS Public Benefit CorpSeries D+$215.1M$2.9B1.53×
Karyopharm Therapeutics Inc. this companySeries D+$205.2M$2.8B1.48×
ADARx Pharmaceuticals, Inc.Series D+$352.5M$2.8B1.48×
Olema Pharmaceuticals, Inc.Series D+$527.4M$2.4B1.24×
Mineralys Therapeutics, Inc.Series D+$118.0M$2.4B1.23×
Endo, Inc.Series D+$170.6M$2.0B1.04×
TORL Biotherapeutics LLCSeries D+$158.3M$1.8B0.96×
UroGen Pharma Ltd.Series D+$120.0M$1.7B0.89×
Renibus Therapeutics, Inc.Series D+$180.1M$1.7B0.87×
Full financing history

Stage is inferred from round size est., not reported on the filing — a round's dollar size maps to a bucket: Pre-Seed <$1.0M · Seed $1.0M–$4.0M · Series A $4.0M–$15M · Series B $15M–$40M · Series C $40M–$100M · Series D+ $100M–$400M · Growth/Late >$400M.

StageAmount · realAnnouncedPost-money · estValue · estConf.
Pre-Seed$700K2010-10-21$3.9M$33.1M85%
Series B$20.5M2013-04-17$113.9M$697.1M85%
Series B$19.0M2013-07-26$105.6M$646.1M85%
Series D+$165.0M2022-12-07$1.4B$2.8B90%
What happened at each round

Step-up, pace versus the sector's normal cadence, and revenue/exemption moves — read straight from the reported round facts reported.

  1. Pre-Seed$700K2010-10-21
    • First recorded raise — entered as Pre-Seed.
    • 3 investors on this round.
  2. Series B$20.5M2013-04-17
    • Raised again after 30 mo — slower than the ~13 mo sector norm.
    • Round 29.3× larger than the prior — scaling up.
    • 8 investors on this round.
  3. Series B$19.0M2013-07-26
    • Came back fast: 3 mo vs the ~13 mo sector norm.
    • Round roughly the size of the prior one.
    • 7 investors on this round.
  4. Series D+$165.0M2022-12-07
    • Raised again after 112 mo — slower than the ~13 mo sector norm.
    • Round 8.7× larger than the prior — scaling up.
    • Switched to Rule 506(b) (was Rule 06).
    • 33 investors on this round.
Intelligence
2026 ~Q4
Modeled next raise · ~49mo cadence
$495.0M
Modeled next size est.range $321.8M$792.0M
8.7×
Last step-up
$16.9M/yr
Capital velocity

Predictive signals are modeled est. from this company's own cadence and step-up, plus sector benchmarks — directional, not advice. Peer set and a CSV export live in your analyst workspace.

Key people & operators

Officers, directors and promoters named in this company's public recordsreported — the people who run it (not its investors). "Also runs" counts come from name-matching across all records, so verify before acting.

PersonRoleAlso runsTied since
Michael Mason3 other2022-12
Paul Brannelly3 other2013-07
Sharon Shacham3 other2010-10
ALAN BARBER2 other2013-04
Mansoor Raza Mirza2 other2010-10
Barry E. Greene1 other2022-12
Deepika R Pakianathan1 other2022-12
Kenneth E. Weg1 other2013-04
Michael Kauffman1 other2010-10
Ronald DePinho1 other2010-10
Barry Raza Greene2013-04
Chen R. Schor2022-12
Christy J. Oliger2022-12
Deepika E. Pakianathan2013-07
Garen G. Bohlin2022-12
Michael Mano2022-12
Peter G. Honig2022-12
Reshma Rangwala2022-12
Richard Paulson2022-12
Sharon E. Shacham2013-04
Sohanya Cheng2022-12
Stephen Mitchener2022-12
Stuart Poulton2022-12
Registry & provenance

Karyopharm Therapeutics Inc. is an official record sourced from the U.S. Securities and Exchange Commission (SEC). U.S. data is aggregated from SEC Form D filings.

United States
Country of record
US
Jurisdiction
1503802
SEC CIK
Similar companies

Nearest neighbours across the whole database — matched on sector, stage and capital scale, and on shared operators (officers or directors named at both companies in public filings). A discovery shortlist, not a valuation cohort — verify before acting, the same way modeled figures are directional.

CompanySectorStageRaised · realValue · estWhy similar
Verastem, Inc.PharmaceuticalsSeries C$163.2M$3.5Bnetwork2 shared operators · same sector
Regulus Therapeutics Inc.PharmaceuticalsSeries B$170.5M$673.2Mnetwork1 shared operator · same sector
Revolution Medicines, Inc.PharmaceuticalsSeries D+$204.2M$3.5Bsame sector · same stage
Ardelyx, Inc.PharmaceuticalsSeries D+$210.4M$3.9Bsame sector · same stage
MAPS Public Benefit CorpPharmaceuticalsSeries D+$215.1M$2.9Bsame sector · same stage
NovaBay Pharmaceuticals, Inc.PharmaceuticalsSeries D+$218.1M$913.2Msame sector · same stage
Beam Therapeutics Inc.PharmaceuticalsSeries D+$218.6M$4.8Bsame sector · same stage
Cingulate Inc.PharmaceuticalsSeries D+$220.0M$5.4Bsame sector · same stage
Semantically similar

Matched by meaning, not labels — a local language model reads each company's name, sector and description and ranks the closest in that learned space. This catches look-alikes that cross sector boundaries; the structured list above explains its matches, this one trusts the text. Directional, like every modeled signal here.

CompanySectorStageValue · estMatch
KALM Therapeutics, Inc.BiotechnologyPre-Seed$2.6M83%
KSQ Therapeutics, Inc.PharmaceuticalsSeries C$2.8B82%
Kp Biosciences, Inc.PharmaceuticalsPre-Seed$13.2M81%
Kinaset Therapeutics, Inc.PharmaceuticalsSeries B$438.1M81%
Decoy Therapeutics, Inc.PharmaceuticalsSeed$3.8M80%
Psy Therapeutics, Inc.PharmaceuticalsSeries A$108.0M80%
Kalytera Therapeutics, Inc.PharmaPre-Seed$35.9M80%
Khloris Biosciences, Inc.PharmaceuticalsSeries A$154.9M79%
Frequently asked
How much funding has Karyopharm Therapeutics Inc. raised?
Karyopharm Therapeutics Inc. has raised approximately $205.2M in disclosed capital across 4 recorded financing rounds, aggregated from public filings.
What is Karyopharm Therapeutics Inc.'s estimated valuation?
Provath's modeled valuation for Karyopharm Therapeutics Inc. is approximately $2.8B (modeled range $785.4M–$4.7B). This is an algorithmic estimate derived from round sizes and same-niche peers — not a quoted or reported figure.
What funding stage is Karyopharm Therapeutics Inc. at?
Karyopharm Therapeutics Inc.'s latest modeled financing stage is Series D+. Its most recent recorded round closed around Wed Dec 07.
What does Karyopharm Therapeutics Inc. do and where is it based?
Karyopharm Therapeutics Inc. operates in the Pharmaceuticals sector, based in NEWTON.
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