Companies · Biotech

Upstream Biotechnology, Inc.New on the radar

DURHAM · Biotech · refined from filed group “Other Technology

Diligence memoA one-page analyst read on Upstream Biotechnology, Inc. — recommendation, valuation, rhythm, risks.
$625K
Total raised · real
1
Rounds
Latest step-up
Top 29%
Sector rank · raised
Pre-Seed
Latest stage · inferred · Tue Aug 26 2025 00:00:00 GMT+0000 (Coordinated Universal Time)

Upstream Biotechnology, Inc. has raised $625K over 1 round; too few niche peers to rank its valuation yet.

Synthesized from the figures below est. — every claim rests on a number shown on this page. Valuation uses the biotech sector profile.

Analyst read est. — computed against this company's niche peers in the same era. Inputs shown; not a quoted figure.

Active
  • Last raise 10 mo ago; this sector typically re-raises about every 11 months.
  • Raising on or ahead of the sector's normal rhythm.
Leadership

No named principal in this company's public records yet — see all operators below.

Explore how these operators interlock with other companies in the operator network.

Where it sits in Biotech

Upstream Biotechnology, Inc. is one of 233 Biotech companies tracked from DURHAM. By capital raised it ranks in the upper tier (ahead of 72% of sector peers), and mid-pack by modeled valuation est..

Ranking is computed against this company's own sector cohort — reported capital is fact; valuation tiers are modeled.

biotech

As reported in public records reported — not modeled.

US
Jurisdiction
Rule 506(b)
Reg D exemption
3
Investors (latest)
2025-08-26
First sale
Amount raised vs valuation, by round

Solid bars are reported offering amounts reported; hatched bars are the modeled post-money valuation est. — both on one shared scale so you can read raise-vs-worth at each round directly. Use the toggles to overlay data labels and the niche-peer / market average value lines.

Amount raised · realModeled valuation · estCumulative funded · real
$0$500K$1.0M$1.5M$2.0MPre-Seed · 2025-08-26 Raised $625K (real) Modeled valuation $1.4M (est)$625K$1.4MPre-Seed2025

The line shows cumulative reported funding over the period; + labels show new capital added between points when there is room. Toggle on-bar figures, plus the niche-peer and market averages, to read this company against its cohort. Benchmarks are modeled medians.

Financing ladder & sequence gaps
Pre-Seed$625K · 2025

Stages are modeled from round size (public records carry no series label). Ladder is contiguous — every modeled rung has a record.

Modeled valuation trajectory
$1.4M
Base estimate est.
$333K
Conservative case
$3.3M
Upside case
$3.5M
Modeled post-money

Round size and date are reported; the stage label is inferred from round size (latest is Pre-Seeda round under $1.0M). Valuation is modeled from stage benchmarks scaled by the biotech sector profile. Directional, not a quoted figure.

Not enough modeled valuation points to chart a trajectory.

Model inputs · modeled:benchmark-stage-stepup-v1
18%
Dilution assumption
Implied ownership sold in the financing.
24%
Survival probability
10% low · 44% high
1.86×/yr
Annual markup
2.52×/yr upside case
0.8 yr
Elapsed time used
0.8 yr actual, capped for stale marks
biotech
Sector profile
Adjusts growth and survival by industry.
Financing rhythm
Avg between rounds
Capital velocity
0.8 yr
On record since
2025
First round
New
First-time filer
How it compares to the market

Benchmarked against 233 companies in Biotech. Each bar is a median (the middle company, not an average — outliers don't skew it). Two yardsticks: real money raised (reported on Form D) and modeled value (our estimate est.). These are whole-sector medians across all stages, except the per-stage row.

Total raised — vs sector median (real $, all stages) 0.1× of median
This company$625K
Sector median$7.8M
Latest round — vs other Pre-Seed rounds in sector (real $, this stage) 2.0× above median
This company$625K
Sector median$315K
Modeled value — vs sector median (estimate, all stages) 0.0× of median
This company$1.4M
Sector median$56.1M

Raised more than 72% of sector peers (real $). Modeled value above 69% of peers (estimate).

Niche peers — same stage & era

A tighter cohort than the sector chart above — only companies at the same stage (Pre-Seed) that last raised in the same ~3-year era, ranked by modeled value est. (not money raised). This is the exact set the analyst read compares against, so a like-for-like cohort is what makes "over/under-valued" meaningful.

This companyCohort peer
$100K$1.0M$10.0M$100K$1.0M$10.0MCapital raised (log)Epoch Biotech, LLC · Pre-Seed Raised $1.0M · modeled $796K (est)Corami Biotech Inc. · Pre-Seed Raised $210K · modeled $328K (est)Upstream Biotechnology, Inc. (this company) Raised $625K · modeled $1.4M (est)Upstream Biotechnology, Inc.
CompanyStageRaised · realValue · estvs peer med.
Upstream Biotechnology, Inc. this companyPre-Seed$625K$1.4M1.77×
Epoch Biotech, LLCPre-Seed$1.0M$796K1.00×
Corami Biotech Inc.Pre-Seed$210K$328K0.41×
Full financing history

Stage is inferred from round size est., not reported on the filing — a round's dollar size maps to a bucket: Pre-Seed <$1.0M · Seed $1.0M–$4.0M · Series A $4.0M–$15M · Series B $15M–$40M · Series C $40M–$100M · Series D+ $100M–$400M · Growth/Late >$400M.

StageAmount · realAnnouncedPost-money · estValue · estConf.
Pre-Seed$625K2025-08-26$3.5M$1.4M90%
What happened at each round

Step-up, pace versus the sector's normal cadence, and revenue/exemption moves — read straight from the reported round facts reported.

  1. Pre-Seed$625K2025-08-26
    • First recorded raise — entered as Pre-Seed.
    • 3 investors on this round.
Intelligence
Modeled next raise
$1.0M
Modeled next size est.range $650K$1.6M
Last step-up
Capital velocity

Predictive signals are modeled est. from this company's own cadence and step-up, plus sector benchmarks — directional, not advice. Peer set and a CSV export live in your analyst workspace.

Key people & operators

Officers, directors and promoters named in this company's public recordsreported — the people who run it (not its investors). "Also runs" counts come from name-matching across all records, so verify before acting.

PersonRoleAlso runsTied since
George H. Greene2025-08
Karen H. LeVert2025-08
Xiao-fang H. Wang2025-08
Xinnian H. Dong2025-08
Registry & provenance

Upstream Biotechnology, Inc. is an official record sourced from the U.S. Securities and Exchange Commission (SEC). U.S. data is aggregated from SEC Form D filings.

United States
Country of record
US
Jurisdiction
2086249
SEC CIK
Similar companies

Nearest neighbours across the whole database — matched on sector, stage and capital scale, and on shared operators (officers or directors named at both companies in public filings). A discovery shortlist, not a valuation cohort — verify before acting, the same way modeled figures are directional.

CompanySectorStageRaised · realValue · estWhy similar
Exponential Genomics Inc.BiotechPre-Seed$600K$33.1Msame sector · same stage
CMTx Biotech, Inc.BiotechPre-Seed$500K$27.6Msame sector · same stage
Empire Genomics Corp.BiotechPre-Seed$500K$16.7Msame sector · same stage
Innovation1 Biotech Inc.BiotechPre-Seed$487K$1.8Msame sector · same stage
Kingsmore Biotech, LLCBiotechPre-Seed$478K$26.4Msame sector · same stage
Antlia Bioscience, Inc.BiotechPre-Seed$887K$12.4Msame sector · same stage
Epoch Biotech, LLCBiotechPre-Seed$1.0M$796Ksame sector · same stage
Bodhi Tree Biotechnology IncBiotechPre-Seed$331K$1.8Msame sector · same stage
Semantically similar

Matched by meaning, not labels — a local language model reads each company's name, sector and description and ranks the closest in that learned space. This catches look-alikes that cross sector boundaries; the structured list above explains its matches, this one trusts the text. Directional, like every modeled signal here.

CompanySectorStageValue · estMatch
Gateway Biotechnology, Inc.BiotechnologyPre-Seed$1.7M85%
Meridian Biotech, LLCBiotechSeed$88.0M84%
Mesa Biotech, Inc.BiotechnologySeries A$108.5M84%
Upstream Research Inc.Other TechnologySeed$6.0M83%
Allied BioScience, Inc.BiotechnologySeries A$74.0M83%
Unity Biotechnology, Inc.BiotechnologySeries D+$2.3B83%
MET Biotechnology Inc.BiotechSeed$12.3M83%
X1 Biotech Inc.BiotechPre-Seed$689K82%
Frequently asked
How much funding has Upstream Biotechnology, Inc. raised?
Upstream Biotechnology, Inc. has raised approximately $625K in disclosed capital across 1 recorded financing round, aggregated from public filings.
What is Upstream Biotechnology, Inc.'s estimated valuation?
Provath's modeled valuation for Upstream Biotechnology, Inc. is approximately $1.4M (modeled range $333K–$3.3M). This is an algorithmic estimate derived from round sizes and same-niche peers — not a quoted or reported figure.
What funding stage is Upstream Biotechnology, Inc. at?
Upstream Biotechnology, Inc.'s latest modeled financing stage is Pre-Seed. Its most recent recorded round closed around Tue Aug 26.
What does Upstream Biotechnology, Inc. do and where is it based?
Upstream Biotechnology, Inc. operates in the Biotech sector, based in DURHAM.
Explore related

See where Upstream Biotechnology, Inc. sits in the wider market — its sector, location and stage cohorts, each with their own leaderboards and capital-flow timelines.

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