Companies · Biotechnology

Silence Therapeutics plc

LONDON · Biotechnology

Diligence memoA one-page analyst read on Silence Therapeutics plc — recommendation, valuation, rhythm, risks.
$54.0M
Total raised · real
2
Rounds
5.4×
Latest step-up
Top 18%
Sector rank · raised
Series C
Latest stage · inferred · Thu Feb 04 2021 00:00:00 GMT+0000 (Coordinated Universal Time)

Silence Therapeutics plc looks fair against its niche peers and is dormant on financing cadence.

Synthesized from the figures below est. — every claim rests on a number shown on this page. Valuation uses the biotech sector profile.

Analyst read est. — computed against this company's niche peers in the same era. Inputs shown; not a quoted figure.

Fair
  • Modeled value is 0.76× the median modeled value of Series C Biotechnology companies in 2019–2021 (120 peers) — value vs value, same stage and era.
  • Within the normal band (76% of peer median) for its niche.
Dormant
  • Last raise 5.4 yr ago; this sector typically re-raises about every 14 months.
  • Silent for over 3× the sector's normal cadence.
Leadership

No named principal in this company's public records yet — see all operators below.

Explore how these operators interlock with other companies in the operator network.

Where it sits in Biotechnology

Silence Therapeutics plc is one of 4291 Biotechnology companies tracked from LONDON. By capital raised it ranks in the upper tier (ahead of 83% of sector peers), and among the largest by modeled valuation est..

Ranking is computed against this company's own sector cohort — reported capital is fact; valuation tiers are modeled.

pharma

As reported in public records reported — not modeled.

US
Jurisdiction
Rule 506(b)
Reg D exemption
12
Investors (latest)
2021-02-04
First sale
Amount raised vs valuation, by round

Solid bars are reported offering amounts reported; hatched bars are the modeled post-money valuation est. — both on one shared scale so you can read raise-vs-worth at each round directly. Use the toggles to overlay data labels and the niche-peer / market average value lines.

Amount raised · realModeled valuation · estCumulative funded · real
$0$500M$1.0B$1.5B$2.0BSeries A · 2010-07-01 Raised $8.5M (real) Modeled valuation $307M (est)$8.5M$307MSeries A2010Series C · 2021-02-04 Raised $45M (real) Modeled valuation $1.5B (est)$45M$1.5BSeries C2021+$45MCumulative $54M

The line shows cumulative reported funding over the period; + labels show new capital added between points when there is room. Toggle on-bar figures, plus the niche-peer and market averages, to read this company against its cohort. Benchmarks are modeled medians.

Financing ladder & sequence gaps
Series A$8.5M · 2010
Series C$45.5M · 2021no Series B on file

Stages are modeled from round size (public records carry no series label). No record for: Pre-Seed, Seed, Series B — the company may have raised it under a different exemption, merged it into an adjacent record, or skipped it. Sequence completeness: 40%.

Modeled valuation trajectory
$1.5B
Base estimate est.
$140.7M
Conservative case
$3.6B
Upside case
$303.3M
Modeled post-money

Round size and date are reported; the stage label is inferred from round size (latest is Series Ca $40M–$100M round). Valuation is modeled from stage benchmarks scaled by the biotech sector profile. Directional, not a quoted figure.

Series A · modeled $307.3M · 2010-07-012010Series C · modeled $1.5B · 2021-02-042021
Model inputs · modeled:benchmark-stage-stepup-v1
15%
Dilution assumption
Implied ownership sold in the financing.
62%
Survival probability
46% low · 72% high
1.46×/yr
Annual markup
1.68×/yr upside case
5.4 yr
Elapsed time used
5.4 yr actual, capped for stale marks
biotech
Sector profile
Adjusts growth and survival by industry.
Financing rhythm
127 mo
Avg between rounds
$5.1M/yr
Capital velocity
16.0 yr
On record since
2010
First round
2
Rounds on file
How it compares to the market

Benchmarked against 4291 companies in Biotechnology. Each bar is a median (the middle company, not an average — outliers don't skew it). Two yardsticks: real money raised (reported on Form D) and modeled value (our estimate est.). These are whole-sector medians across all stages, except the per-stage row.

Total raised — vs sector median (real $, all stages) 7.5× above median
This company$54.0M
Sector median$7.2M
Latest round — vs other Series C rounds in sector (real $, this stage) 1.0× of median
This company$45.5M
Sector median$46.5M
Modeled value — vs sector median (estimate, all stages) 23× above median
This company$1.5B
Sector median$64.2M

Raised more than 83% of sector peers (real $). Modeled value above 92% of peers (estimate).

Niche peers — same stage & era

A tighter cohort than the sector chart above — only companies at the same stage (Series C) that last raised in the same ~3-year era, ranked by modeled value est. (not money raised). This is the exact set the analyst read compares against, so a like-for-like cohort is what makes "over/under-valued" meaningful. This company ranks #84 of 120.

This companyCohort peer
$1.0B$10.0B$10.0M$100.0M$1.0BCapital raised (log)Stem Biotech LLC · Series C Raised $100.0M · modeled $4.1B (est)Kinnate Biopharma Inc. · Series C Raised $172.5M · modeled $3.9B (est)Arcutis Biotherapeutics, Inc. · Series C Raised $94.5M · modeled $3.9B (est)DNA Research INST LLC · Series C Raised $94.5M · modeled $3.7B (est)M3 Biotechnology, Inc. · Series C Raised $107.3M · modeled $3.6B (est)Checkmate Pharmaceuticals, Inc. · Series C Raised $185.1M · modeled $3.5B (est)Black Diamond Therapeutics, Inc. · Series C Raised $146.3M · modeled $3.5B (est)Finch Therapeutics Group, Inc. · Series C Raised $179.9M · modeled $3.4B (est)Shattuck Labs, Inc. · Series C Raised $165.4M · modeled $3.4B (est)TScan Therapeutics, Inc. · Series C Raised $123.3M · modeled $3.3B (est)Edgewise Therapeutics, Inc. · Series C Raised $120.1M · modeled $3.3B (est)Miragen Therapeutics, Inc. · Series C Raised $197.8M · modeled $3.3B (est)Silence Therapeutics plc (this company) Raised $54.0M · modeled $1.5B (est)Silence Therapeutics plc
CompanyStageRaised · realValue · estvs peer med.
Stem Biotech LLCSeries C$100.0M$4.1B2.11×
Kinnate Biopharma Inc.Series C$172.5M$3.9B2.02×
Arcutis Biotherapeutics, Inc.Series C$94.5M$3.9B1.99×
DNA Research INST LLCSeries C$94.5M$3.7B1.88×
M3 Biotechnology, Inc.Series C$107.3M$3.6B1.88×
Checkmate Pharmaceuticals, Inc.Series C$185.1M$3.5B1.79×
Black Diamond Therapeutics, Inc.Series C$146.3M$3.5B1.79×
Finch Therapeutics Group, Inc.Series C$179.9M$3.4B1.78×
Shattuck Labs, Inc.Series C$165.4M$3.4B1.75×
TScan Therapeutics, Inc.Series C$123.3M$3.3B1.71×
Edgewise Therapeutics, Inc.Series C$120.1M$3.3B1.70×
Miragen Therapeutics, Inc.Series C$197.8M$3.3B1.69×
Silence Therapeutics plc this companySeries C$54.0M$1.5B0.76×
Full financing history

Stage is inferred from round size est., not reported on the filing — a round's dollar size maps to a bucket: Pre-Seed <$1.0M · Seed $1.0M–$4.0M · Series A $4.0M–$15M · Series B $15M–$40M · Series C $40M–$100M · Series D+ $100M–$400M · Growth/Late >$400M.

StageAmount · realAnnouncedPost-money · estValue · estConf.
Series A$8.5M2010-07-01$38.6M$307.3M85%
Series C$45.5M2021-02-04$303.3M$1.5B90%
What happened at each round

Step-up, pace versus the sector's normal cadence, and revenue/exemption moves — read straight from the reported round facts reported.

  1. Series A$8.5M2010-07-01
    • First recorded raise — entered as Series A.
  2. Series C$45.5M2021-02-04
    • Raised again after 127 mo — slower than the ~14 mo sector norm.
    • Round 5.4× larger than the prior — scaling up.
    • Switched to Rule 506(b) (was Rule 06).
    • 12 investors on this round.
Intelligence
2031 ~Q3
Modeled next raise · ~127mo cadence
$136.5M
Modeled next size est.range $88.7M$218.4M
5.4×
Last step-up
$5.1M/yr
Capital velocity

Predictive signals are modeled est. from this company's own cadence and step-up, plus sector benchmarks — directional, not advice. Peer set and a CSV export live in your analyst workspace.

Key people & operators

Officers, directors and promoters named in this company's public recordsreported — the people who run it (not its investors). "Also runs" counts come from name-matching across all records, so verify before acting.

PersonRoleAlso runsTied since
Jeremy Curnock Cook3 other2010-07
Craig Tooman2 other2021-02
Giles Campion1 other2021-02
Iain Ross1 other2010-07
Alistair Gray2021-02
Annette Clancy2010-07
Barbara Ruskin2021-02
Bernd Curnock Wetzel2010-07
Dave Lemus2021-02
David Curnock U'Prichard2010-07
James Ede-Golightly2021-02
Jerry Curnock Randall2010-07
Mark Rothera2021-02
Melvyn Curnock Davies2010-07
Michael H. Davidson2021-02
Peter Curnock Reynolds2010-07
Romano Steven2021-02
Registry & provenance

Silence Therapeutics plc is an official record sourced from the U.S. Securities and Exchange Commission (SEC). U.S. data is aggregated from SEC Form D filings.

United States
Country of record
US
Jurisdiction
1479615
SEC CIK
Similar companies

Nearest neighbours across the whole database — matched on sector, stage and capital scale, and on shared operators (officers or directors named at both companies in public filings). A discovery shortlist, not a valuation cohort — verify before acting, the same way modeled figures are directional.

CompanySectorStageRaised · realValue · estWhy similar
Prosensa Holding N.V.BiotechnologySeries C$50.5M$2.1Bnetwork1 shared operator · same sector · same stage
AmpliPhi Biosciences CorpBiotechnologySeries B$57.3M$516.0Mnetwork1 shared operator · same sector
Puma Biotechnology, Inc.BiotechnologySeries C$55.0M$2.3Bsame sector · same stage
Mahzi Therapeutics Inc.BiotechnologySeries C$52.6M$1.3Bsame sector · same stage
Biomea Fusion, Inc.BiotechnologySeries C$56.0M$1.9Bsame sector · same stage
Aurinia Pharmaceuticals Inc.BiotechnologySeries C$52.0M$2.1Bsame sector · same stage
Pardes Biosciences, IncBiotechnologySeries C$51.6M$1.7Bsame sector · same stage
PanOptica, Inc.BiotechnologySeries C$57.3M$1.7Bsame sector · same stage
Semantically similar

Matched by meaning, not labels — a local language model reads each company's name, sector and description and ranks the closest in that learned space. This catches look-alikes that cross sector boundaries; the structured list above explains its matches, this one trusts the text. Directional, like every modeled signal here.

CompanySectorStageValue · estMatch
Stealth Therapeutics, Inc.BiotechnologySeed$6.2M84%
Cessation Therapeutics, Inc.BiotechnologySeries A$5.9M81%
Courage Therapeutics, Inc.BiotechnologySeries A$15.9M79%
RevOpsis Therapeutics CorpBiotechnologyPre-Seed$9.9M79%
Stealth BioTherapeutics CorpBiotechnologySeries B$793.8M78%
Sound Pharmaceuticals IncBiotechnologySeries A$304.0M78%
Intrommune Therapeutics, Inc.BiotechnologySeries B$1.9M78%
Spotlight Therapeutics, Inc.BiotechnologySeries B$687.7M78%
Frequently asked
How much funding has Silence Therapeutics plc raised?
Silence Therapeutics plc has raised approximately $54.0M in disclosed capital across 2 recorded financing rounds, aggregated from public filings.
What is Silence Therapeutics plc's estimated valuation?
Provath's modeled valuation for Silence Therapeutics plc is approximately $1.5B (modeled range $140.7M–$3.6B). This is an algorithmic estimate derived from round sizes and same-niche peers — not a quoted or reported figure.
What funding stage is Silence Therapeutics plc at?
Silence Therapeutics plc's latest modeled financing stage is Series C. Its most recent recorded round closed around Thu Feb 04.
What does Silence Therapeutics plc do and where is it based?
Silence Therapeutics plc operates in the Biotechnology sector, based in LONDON.
Explore related

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