Companies · Biotechnology

SightStream Biotherapeutics, Inc.

WALPOLE · Biotechnology

Diligence memoA one-page analyst read on SightStream Biotherapeutics, Inc. — recommendation, valuation, rhythm, risks.
$5.1M
Total raised · real
3
Rounds
7.2×
Latest step-up
Top 56%
Sector rank · raised
Seed
Latest stage · inferred · Thu Oct 02 2025 00:00:00 GMT+0000 (Coordinated Universal Time)

SightStream Biotherapeutics, Inc. looks fair against its niche peers and is active on financing cadence.

Synthesized from the figures below est. — every claim rests on a number shown on this page. Valuation uses the biotech sector profile.

Analyst read est. — computed against this company's niche peers in the same era. Inputs shown; not a quoted figure.

Fair
  • Modeled value is 0.95× the median modeled value of Seed Biotechnology companies in 2025–2027 (99 peers) — value vs value, same stage and era.
  • Within the normal band (95% of peer median) for its niche.
Active
  • Last raise 9 mo ago; this sector typically re-raises about every 14 months.
  • Raising on or ahead of the sector's normal rhythm.
Leadership

No named principal in this company's public records yet — see all operators below.

Explore how these operators interlock with other companies in the operator network.

Where it sits in Biotechnology

SightStream Biotherapeutics, Inc. is one of 4293 Biotechnology companies tracked from WALPOLE. By capital raised it ranks mid-pack (ahead of 45% of sector peers), and in the long tail by modeled valuation est..

Ranking is computed against this company's own sector cohort — reported capital is fact; valuation tiers are modeled.

As reported in public records reported — not modeled.

US
Jurisdiction
Rule 506(b)
Reg D exemption
9
Investors (latest)
2025-10-02
First sale
Amount raised vs valuation, by round

Solid bars are reported offering amounts reported; hatched bars are the modeled post-money valuation est. — both on one shared scale so you can read raise-vs-worth at each round directly. Use the toggles to overlay data labels and the niche-peer / market average value lines.

Amount raised · realModeled valuation · estCumulative funded · real
$0$13M$25M$38M$50MSeed · 2022-05-25 Raised $2.9M (real) Modeled valuation $45M (est)$2.9M$45MSeed2022Seed · 2022-05-25 Raised $1.9M (real) Modeled valuation $30M (est)$1.9M$30MSeed2022Seed · 2022-05-25 Raised $3.1M (real) Modeled valuation $48M (est)$3.1M$48MSeed2022Seed · 2023-08-11 Raised $250K (real) Modeled valuation $2.0M (est)$250K$2.0MSeed2023Seed · 2025-10-02 Raised $1.8M (real) Modeled valuation $4.3M (est)$1.8M$4.3MSeed2025+$1.9M+$3.1M+$250K+$1.8MCumulative $9.9M

The line shows cumulative reported funding over the period; + labels show new capital added between points when there is room. Toggle on-bar figures, plus the niche-peer and market averages, to read this company against its cohort. Benchmarks are modeled medians.

Financing ladder & sequence gaps
Seed$2.9M · 2022
Seed extension$1.9M · 2022
Seed extension$3.1M · 2022
Seed extension$250K · 2023
Seed extension$1.8M · 2025

Stages are modeled from round size (public records carry no series label). No record for: Pre-Seed — the company may have raised it under a different exemption, merged it into an adjacent record, or skipped it. Sequence completeness: 50%.

Modeled valuation trajectory
$4.3M
Base estimate est.
$1.3M
Conservative case
$8.2M
Upside case
$9.0M
Modeled post-money

Round size and date are reported; the stage label is inferred from round size (latest is Seeda $1.0M–$4.0M round). Valuation is modeled from stage benchmarks scaled by the biotech sector profile. Directional, not a quoted figure.

Seed · modeled $45.3M · 2022-05-252022Seed · modeled $29.5M · 2022-05-25Seed · modeled $47.6M · 2022-05-25Seed · modeled $2.0M · 2023-08-11Seed · modeled $4.3M · 2025-10-022025
Model inputs · modeled:benchmark-stage-stepup-v1
20%
Dilution assumption
Implied ownership sold in the financing.
32%
Survival probability
14% low · 50% high
1.74×/yr
Annual markup
2.28×/yr upside case
0.8 yr
Elapsed time used
0.8 yr actual, capped for stale marks
biotech
Sector profile
Adjusts growth and survival by industry.
Financing rhythm
10 mo
Avg between rounds
$1.5M/yr
Capital velocity
4.1 yr
On record since
2022
First round
5
Rounds on file
How it compares to the market

Benchmarked against 4293 companies in Biotechnology. Each bar is a median (the middle company, not an average — outliers don't skew it). Two yardsticks: real money raised (reported on Form D) and modeled value (our estimate est.). These are whole-sector medians across all stages, except the per-stage row.

Total raised — vs sector median (real $, all stages) 0.7× of median
This company$5.1M
Sector median$7.2M
Latest round — vs other Seed rounds in sector (real $, this stage) 1.0× above median
This company$1.8M
Sector median$1.7M
Modeled value — vs sector median (estimate, all stages) 0.1× of median
This company$4.3M
Sector median$64.2M

Raised more than 45% of sector peers (real $). Modeled value above 9% of peers (estimate).

Niche peers — same stage & era

A tighter cohort than the sector chart above — only companies at the same stage (Seed) that last raised in the same ~3-year era, ranked by modeled value est. (not money raised). This is the exact set the analyst read compares against, so a like-for-like cohort is what makes "over/under-valued" meaningful. This company ranks #55 of 99.

This companyCohort peer
$1.0M$10.0M$100.0M$1.0M$10.0MCapital raised (log)Carna Inc. · Seed Raised $3.4M · modeled $12.4M (est)NRX Pharmaceuticals, Inc. · Seed Raised $3.5M · modeled $12.3M (est)Vicora, Inc. · Seed Raised $3.4M · modeled $11.9M (est)MH3D, Inc. · Seed Raised $3.3M · modeled $11.9M (est)Oral Genome Corp. · Seed Raised $3.1M · modeled $11.2M (est)Synlico Inc. · Seed Raised $5.2M · modeled $10.1M (est)Auxilium Biotechnologies Inc. · Seed Raised $7.2M · modeled $9.7M (est)Silexion Therapeutics Corp · Seed Raised $3.6M · modeled $9.6M (est)Bodark Investment Group LP · Seed Raised $3.3M · modeled $9.4M (est)Sower Solas I Sidecar III, LLC · Seed Raised $3.5M · modeled $9.3M (est)Sift Biosciences, Inc. · Seed Raised $3.8M · modeled $8.5M (est)SiVEC Biotechnologies, Inc. · Seed Raised $3.3M · modeled $8.4M (est)SightStream Biotherapeutics, Inc. (this company) Raised $5.1M · modeled $4.3M (est)SightStream Biotherapeutics, Inc.
CompanyStageRaised · realValue · estvs peer med.
Carna Inc.Seed$3.4M$12.4M2.72×
NRX Pharmaceuticals, Inc.Seed$3.5M$12.3M2.70×
Vicora, Inc.Seed$3.4M$11.9M2.61×
MH3D, Inc.Seed$3.3M$11.9M2.61×
Oral Genome Corp.Seed$3.1M$11.2M2.45×
Synlico Inc.Seed$5.2M$10.1M2.22×
Auxilium Biotechnologies Inc.Seed$7.2M$9.7M2.13×
Silexion Therapeutics CorpSeed$3.6M$9.6M2.10×
Bodark Investment Group LPSeed$3.3M$9.4M2.06×
Sower Solas I Sidecar III, LLCSeed$3.5M$9.3M2.05×
Sift Biosciences, Inc.Seed$3.8M$8.5M1.85×
SiVEC Biotechnologies, Inc.Seed$3.3M$8.4M1.85×
SightStream Biotherapeutics, Inc. this companySeed$5.1M$4.3M0.95×
Full financing history

Stage is inferred from round size est., not reported on the filing — a round's dollar size maps to a bucket: Pre-Seed <$1.0M · Seed $1.0M–$4.0M · Series A $4.0M–$15M · Series B $15M–$40M · Series C $40M–$100M · Series D+ $100M–$400M · Growth/Late >$400M.

StageAmount · realAnnouncedPost-money · estValue · estConf.
Seed$2.9M2022-05-25$14.6M$45.3M90%
Seed$1.9M2022-05-25$9.5M$29.5M90%
Seed$3.1M2022-05-25$15.3M$47.6M90%
Seed$250K2023-08-11$1.3M$2.0M90%
Seed$1.8M2025-10-02$9.0M$4.3M90%
What happened at each round

Step-up, pace versus the sector's normal cadence, and revenue/exemption moves — read straight from the reported round facts reported.

  1. Seed$2.9M2022-05-25
    • First recorded raise — entered as Seed.
    • 19 investors on this round.
  2. Seed$1.9M2022-05-25
    • Filed alongside the prior round (same month) — likely a tranche or amendment.
    • Round 1.5× smaller than the prior — bridge or down round.
    • 13 investors on this round.
  3. Seed$3.1M2022-05-25
    • Filed alongside the prior round (same month) — likely a tranche or amendment.
    • Round 1.6× larger than the prior — scaling up.
    • 21 investors on this round.
  4. Seed$250K2023-08-11
    • Raised 15 mo later, in step with the ~14 mo sector norm.
    • Round 12.3× smaller than the prior — bridge or down round.
    • 2 investors on this round.
  5. Seed$1.8M2025-10-02
    • Raised again after 26 mo — slower than the ~14 mo sector norm.
    • Round 7.2× larger than the prior — scaling up.
    • 9 investors on this round.
Intelligence
2026 ~Q3
Modeled next raise · ~10mo cadence
$5.4M
Modeled next size est.range $3.5M$8.6M
7.2×
Last step-up
$1.5M/yr
Capital velocity

Predictive signals are modeled est. from this company's own cadence and step-up, plus sector benchmarks — directional, not advice. Peer set and a CSV export live in your analyst workspace.

Key people & operators

Officers, directors and promoters named in this company's public recordsreported — the people who run it (not its investors). "Also runs" counts come from name-matching across all records, so verify before acting.

PersonRoleAlso runsTied since
David Neafus6 other2022-05
Jason Werner2 other2022-05
Reza Dana2 other2022-05
Samuel Wu1 other2025-10
Wenkai Xiang1 other2025-10
Jiagang Zhao2022-05
Registry & provenance

SightStream Biotherapeutics, Inc. is an official record sourced from the U.S. Securities and Exchange Commission (SEC). U.S. data is aggregated from SEC Form D filings.

United States
Country of record
US
Jurisdiction
1932386
SEC CIK
Similar companies

Nearest neighbours across the whole database — matched on sector, stage and capital scale, and on shared operators (officers or directors named at both companies in public filings). A discovery shortlist, not a valuation cohort — verify before acting, the same way modeled figures are directional.

CompanySectorStageRaised · realValue · estWhy similar
Nayan Therapeutics, Inc.BiotechnologySeed$3.0M$133.2Mnetwork1 shared operator · same sector · same stage
Cellphire, Inc.BiotechnologySeed$5.0M$6.7Msame sector · same stage
Salutaris Medical Devices IncBiotechnologySeed$5.4M$6.4Msame sector · same stage
Efemoral Medical, Inc.BiotechnologySeed$4.7M$4.6Msame sector · same stage
Drug Delivery Company, LLCBiotechnologySeed$4.7M$3.1Msame sector · same stage
Long Bridge Medical, Inc.BiotechnologySeed$4.6M$3.9Msame sector · same stage
Elevai Labs Inc.BiotechnologySeed$5.7M$1.9Msame sector · same stage
Abvc Biopharma, Inc.BiotechnologySeed$4.5M$3.9Msame sector · same stage
Semantically similar

Matched by meaning, not labels — a local language model reads each company's name, sector and description and ranks the closest in that learned space. This catches look-alikes that cross sector boundaries; the structured list above explains its matches, this one trusts the text. Directional, like every modeled signal here.

CompanySectorStageValue · estMatch
Sight Sciences, Inc.BiotechnologySeries B$778.7M89%
Insight Optics, Inc.BiotechnologyPre-Seed$16.8M87%
Perceive Biotherapeutics, Inc.BiotechnologySeries B$544.6M87%
Arcutis Biotherapeutics, Inc.BiotechnologySeries C$3.9B87%
Sensei Biotherapeutics, Inc.BiotechnologySeries D+$2.2B86%
Biotheryx, Inc.BiotechnologySeries C$2.7B86%
Visiongate IncBiotechnologySeries B$148.8M85%
Genome Insight, Inc.BiotechnologySeries A$39.9M85%
Frequently asked
How much funding has SightStream Biotherapeutics, Inc. raised?
SightStream Biotherapeutics, Inc. has raised approximately $5.1M in disclosed capital across 3 recorded financing rounds, aggregated from public filings.
What is SightStream Biotherapeutics, Inc.'s estimated valuation?
Provath's modeled valuation for SightStream Biotherapeutics, Inc. is approximately $4.3M (modeled range $1.3M–$8.2M). This is an algorithmic estimate derived from round sizes and same-niche peers — not a quoted or reported figure.
What funding stage is SightStream Biotherapeutics, Inc. at?
SightStream Biotherapeutics, Inc.'s latest modeled financing stage is Seed. Its most recent recorded round closed around Thu Oct 02.
What does SightStream Biotherapeutics, Inc. do and where is it based?
SightStream Biotherapeutics, Inc. operates in the Biotechnology sector, based in WALPOLE.
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