Companies · Biotechnology

Cofactor Genomics, Inc.Summer 2015Active

San Francisco · MO, USA · Biotechnology · founded 2015 · http://cofactorgenomics.com

Diligence memoA one-page analyst read on Cofactor Genomics, Inc. — recommendation, valuation, rhythm, risks.
$18.8M
Total raised · real
3
Rounds
0.2×
Latest step-up
Top 34%
Sector rank · raised
Series A
Latest stage · inferred · Thu Jul 20 2023 00:00:00 GMT+0000 (Coordinated Universal Time)

Cofactor Genomics, Inc. looks under-valued against its niche peers and is at-risk on financing cadence.

Synthesized from the figures below est. — every claim rests on a number shown on this page. Valuation uses the biotech sector profile.

Analyst read est. — computed against this company's niche peers in the same era. Inputs shown; not a quoted figure.

Under-valued
  • Modeled value is 0.22× the median modeled value of Series A Biotechnology companies in 2022–2024 (303 peers) — value vs value, same stage and era.
At-risk
  • Last raise 2.9 yr ago; this sector typically re-raises about every 14 months.
  • Past due for a raise versus sector cadence — watch for distress or a bridge.
Leadership

No named principal in this company's public records yet — see all operators below.

Explore how these operators interlock with other companies in the operator network.

Where it sits in Biotechnology

Cofactor Genomics, Inc. is one of 4291 Biotechnology companies tracked from San Francisco, MO, USA, on record since 2015. By capital raised it ranks mid-pack (ahead of 67% of sector peers), and in the long tail by modeled valuation est..

Ranking is computed against this company's own sector cohort — reported capital is fact; valuation tiers are modeled.

AI analyst read est. — model-extracted from this company's public description, not a verified fact. 30%

operates a technology-led product inferred from public copy

Grounded in: “You are a venture analyst

Cofactor closes the precision medicine gap with predictive diagnostics

Cofactor uses RNA and Predictive Immune Modeling to build better biomarkers and improve patient outcomes. Led by Jarret Glasscock and a group of expert human genome scientists,Cofactor has built a new category of diagnostic technology powered by unique and powerful RNA data models built on terabytes of data. The team recently had their technology validation peer-reviewed by the organizations that set standards for diagnostic technology (CAP, AMP) and is publishing in the Journal of Molecular Diagnostics. In addition, the team made news when Cancer Physicians who sit on the committee for patient treatment guidelines (NCCN) presented a clinical study using Cofactor’s technology showing superiority in predicting the patients who will respond to immunotherapy. This initial application is an acute problem recognized widely in the rapidly developing immunotherapy industry and represents north of a billion dollar TAM. After a number of recent key milestones, the team is taking the technology more broadly to 50% of cancers diagnosed in the US. Current investors include Menlo Ventures, DCVC, and Ascension Ventures (this last investor representing the funding arm for 13 National U.S. Healthcare Systems).

biotechhealthtechmedical-devices
Find Cofactor Genomics, Inc. online

As reported in public records reported — not modeled.

US
Jurisdiction
Rule 506(b)
Reg D exemption
2
Investors (latest)
2023-07-20
First sale
Amount raised vs valuation, by round

Solid bars are reported offering amounts reported; hatched bars are the modeled post-money valuation est. — both on one shared scale so you can read raise-vs-worth at each round directly. Use the toggles to overlay data labels and the niche-peer / market average value lines.

Amount raised · realModeled valuation · estCumulative funded · real
$0$125M$250M$375M$500MSeries A · 2017-06-14 Raised $11M (real) Modeled valuation $386M (est)$11M$386MSeries A2017Series A · 2021-12-08 Raised $6.9M (real) Modeled valuation $125M (est)$6.9M$125MSeries A2021Series A · 2023-07-20 Raised $1.2M (real) Modeled valuation $9.7M (est)$1.2M$9.7MSeries A2023+$6.9M+$1.2MCumulative $19M

The line shows cumulative reported funding over the period; + labels show new capital added between points when there is room. Toggle on-bar figures, plus the niche-peer and market averages, to read this company against its cohort. Benchmarks are modeled medians.

Financing ladder & sequence gaps
Series A$10.7M · 2017
Series A extension$6.9M · 2021
Series A extension$1.2M · 2023

Stages are modeled from round size (public records carry no series label). No record for: Pre-Seed, Seed — the company may have raised it under a different exemption, merged it into an adjacent record, or skipped it. Sequence completeness: 33%.

Modeled valuation trajectory
$9.7M
Base estimate est.
$1.3M
Conservative case
$26.2M
Upside case
$5.3M
Modeled post-money

Round size and date are reported; the stage label is inferred from round size (latest is Series Aa $4.0M–$15M round). Valuation is modeled from stage benchmarks scaled by the biotech sector profile. Directional, not a quoted figure.

Series A · modeled $386.2M · 2017-06-142017Series A · modeled $124.7M · 2021-12-08Series A · modeled $9.7M · 2023-07-202023
Model inputs · modeled:benchmark-stage-stepup-v1
22%
Dilution assumption
Implied ownership sold in the financing.
44%
Survival probability
24% low · 60% high
1.62×/yr
Annual markup
2.04×/yr upside case
3.0 yr
Elapsed time used
3.0 yr actual, capped for stale marks
biotech
Sector profile
Adjusts growth and survival by industry.
Financing rhythm
37 mo
Avg between rounds
$3.1M/yr
Capital velocity
9.0 yr
On record since
2017
First round
3
Rounds on file
How it compares to the market

Benchmarked against 4291 companies in Biotechnology. Each bar is a median (the middle company, not an average — outliers don't skew it). Two yardsticks: real money raised (reported on Form D) and modeled value (our estimate est.). These are whole-sector medians across all stages, except the per-stage row.

Total raised — vs sector median (real $, all stages) 2.6× above median
This company$18.8M
Sector median$7.2M
Latest round — vs other Series A rounds in sector (real $, this stage) 0.2× of median
This company$1.2M
Sector median$5.4M
Modeled value — vs sector median (estimate, all stages) 0.2× of median
This company$9.7M
Sector median$64.2M

Raised more than 67% of sector peers (real $). Modeled value above 18% of peers (estimate).

Niche peers — same stage & era

A tighter cohort than the sector chart above — only companies at the same stage (Series A) that last raised in the same ~3-year era, ranked by modeled value est. (not money raised). This is the exact set the analyst read compares against, so a like-for-like cohort is what makes "over/under-valued" meaningful. This company ranks #264 of 303.

This companyCohort peer
$1.0M$10.0M$100.0M$1.0B$10.0M$100.0MCapital raised (log)GeoVax Labs, Inc. · Series A Raised $39.1M · modeled $217.0M (est)Cellinfinity Bio Holding Company, LLC · Series A Raised $13.2M · modeled $215.9M (est)Adient Medical, Inc. · Series A Raised $18.2M · modeled $206.8M (est)Entegrion Inc · Series A Raised $22.7M · modeled $191.3M (est)BCD Bioscience, Inc. · Series A Raised $16.4M · modeled $188.9M (est)Pragma Biosciences Inc. · Series A Raised $14.5M · modeled $186.0M (est)MicroByre, Inc. · Series A Raised $16.1M · modeled $185.7M (est)Cardiac Insight, Inc. · Series A Raised $38.1M · modeled $183.8M (est)Cardiac Implants LLC · Series A Raised $13.5M · modeled $178.2M (est)Abintus Bio, Inc. · Series A Raised $13.7M · modeled $177.2M (est)Mosaic Biosciences, Inc. · Series A Raised $14.7M · modeled $176.1M (est)Mazen Animal Health Inc. · Series A Raised $13.5M · modeled $168.8M (est)Cofactor Genomics, Inc. (this company) Raised $18.8M · modeled $9.7M (est)Cofactor Genomics, Inc.
CompanyStageRaised · realValue · estvs peer med.
GeoVax Labs, Inc.Series A$39.1M$217.0M4.90×
Cellinfinity Bio Holding Company, LLCSeries A$13.2M$215.9M4.87×
Adient Medical, Inc.Series A$18.2M$206.8M4.67×
Entegrion IncSeries A$22.7M$191.3M4.32×
BCD Bioscience, Inc.Series A$16.4M$188.9M4.27×
Pragma Biosciences Inc.Series A$14.5M$186.0M4.20×
MicroByre, Inc.Series A$16.1M$185.7M4.19×
Cardiac Insight, Inc.Series A$38.1M$183.8M4.15×
Cardiac Implants LLCSeries A$13.5M$178.2M4.02×
Abintus Bio, Inc.Series A$13.7M$177.2M4.00×
Mosaic Biosciences, Inc.Series A$14.7M$176.1M3.98×
Mazen Animal Health Inc.Series A$13.5M$168.8M3.81×
Cofactor Genomics, Inc. this companySeries A$18.8M$9.7M0.22×
Full financing history

Stage is inferred from round size est., not reported on the filing — a round's dollar size maps to a bucket: Pre-Seed <$1.0M · Seed $1.0M–$4.0M · Series A $4.0M–$15M · Series B $15M–$40M · Series C $40M–$100M · Series D+ $100M–$400M · Growth/Late >$400M.

StageAmount · realAnnouncedPost-money · estValue · estConf.
Series A$10.7M2017-06-14$48.6M$386.2M90%
Series A$6.9M2021-12-08$31.4M$124.7M90%
Series A$1.2M2023-07-20$5.3M$9.7M90%
What happened at each round

Step-up, pace versus the sector's normal cadence, and revenue/exemption moves — read straight from the reported round facts reported.

  1. Series A$10.7M2017-06-14
    • First recorded raise — entered as Series A.
    • 23 investors on this round.
  2. Series A$6.9M2021-12-08
    • Raised again after 54 mo — slower than the ~14 mo sector norm.
    • Round 1.5× smaller than the prior — bridge or down round.
    • 9 investors on this round.
  3. Series A$1.2M2023-07-20
    • Raised 19 mo later, in step with the ~14 mo sector norm.
    • Round 5.9× smaller than the prior — bridge or down round.
    • 2 investors on this round.
Intelligence
2026 ~Q3
Modeled next raise · ~37mo cadence
$1.2M
Modeled next size est.range $1.2M$1.9M
0.2×
Last step-up
$3.1M/yr
Capital velocity

Predictive signals are modeled est. from this company's own cadence and step-up, plus sector benchmarks — directional, not advice. Peer set and a CSV export live in your analyst workspace.

Key people & operators

Officers, directors and promoters named in this company's public recordsreported — the people who run it (not its investors). "Also runs" counts come from name-matching across all records, so verify before acting.

PersonRoleAlso runsTied since
Mark Siegel7 other2017-06
John Kuelper5 other2021-12
Armen Vidian4 other2021-12
William Hagstrom3 other2021-12
Jon Armstrong1 other2017-06
David Messina2021-12
Jarret Glasscock2021-12
Jarret Glassock2017-06
Matthew A. Ocko2017-06
Registry & provenance

Cofactor Genomics, Inc. is an official record sourced from the U.S. Securities and Exchange Commission (SEC). U.S. data is aggregated from SEC Form D filings.

United States
Country of record
US
Jurisdiction
1710475
SEC CIK
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Frequently asked
How much funding has Cofactor Genomics, Inc. raised?
Cofactor Genomics, Inc. has raised approximately $18.8M in disclosed capital across 3 recorded financing rounds, aggregated from public filings.
What is Cofactor Genomics, Inc.'s estimated valuation?
Provath's modeled valuation for Cofactor Genomics, Inc. is approximately $9.7M (modeled range $1.3M–$26.2M). This is an algorithmic estimate derived from round sizes and same-niche peers — not a quoted or reported figure.
What funding stage is Cofactor Genomics, Inc. at?
Cofactor Genomics, Inc.'s latest modeled financing stage is Series A. Its most recent recorded round closed around Thu Jul 20.
What does Cofactor Genomics, Inc. do and where is it based?
Cofactor Genomics, Inc. operates in the Biotechnology sector, based in San Francisco, MO, USA. Cofactor closes the precision medicine gap with predictive diagnostics
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