Companies · Biotechnology

Castle Creek Biosciences, Inc.

Exton · Biotechnology · https://castlecreekbio.com/

Diligence memoA one-page analyst read on Castle Creek Biosciences, Inc. — recommendation, valuation, rhythm, risks.
$839.8M
Total raised · real
6
Rounds
0.7×
Latest step-up
Top 1%
Sector rank · raised
Growth/Late
Latest stage · inferred · Mon Feb 24 2025 00:00:00 GMT+0000 (Coordinated Universal Time)

Castle Creek Biosciences, Inc. looks under-valued against its niche peers and is active on financing cadence.

Synthesized from the figures below est. — every claim rests on a number shown on this page. Valuation uses the biotech sector profile.

Analyst read est. — computed against this company's niche peers in the same era. Inputs shown; not a quoted figure.

Under-valued
  • Modeled value is 0.28× the median modeled value of Growth/Late Biotechnology companies in 2025–2027 (5 peers) — value vs value, same stage and era.
Active
  • Last raise 16 mo ago; this sector typically re-raises about every 14 months.
  • Raising on or ahead of the sector's normal rhythm.
Leadership

No named principal in this company's public records yet — see all operators below.

Explore how these operators interlock with other companies in the operator network.

Where it sits in Biotechnology

Castle Creek Biosciences, Inc. is one of 4293 Biotechnology companies tracked from Exton. By capital raised it ranks among the largest (ahead of 100% of sector peers), and in the upper tier by modeled valuation est..

Ranking is computed against this company's own sector cohort — reported capital is fact; valuation tiers are modeled.

AI analyst read est. — model-extracted from this company's public description, not a verified fact. 30%

operates a technology-led product inferred from public copy

Grounded in: “You are a venture analyst

Dedicated to making life better for people suffering from rare diseases with few or no treatment options

Dedicated to making life better for people suffering from rare diseases with few or no treatment options “ We are building a leading cell and gene therapy company for patients and families seeking relief from devastating genetic diseases. ” Courtesy of debra—The Dystrophic Epidermolysis Bullosa Research Association of America and the Oliveira family. Used with permission. Courtesy of EB Research Partnership and the Attar family. Used with permission. Castle Creek Biosciences, Inc. 405 Eagleview Boulevard Exton, PA 19341 ©2026 Castle Creek Biosciences, Inc. All Rights Reserved. The registered dual crescent logo and “Castle Creek Biosciences” are trademarks of Castle Creek Biosciences, LLC.

biotech
Find Castle Creek Biosciences, Inc. online

As reported in public records reported — not modeled.

US
Jurisdiction
Rule 506(b)
Reg D exemption
30
Investors (latest)
2025-02-24
First sale
Amount raised vs valuation, by round

Solid bars are reported offering amounts reported; hatched bars are the modeled post-money valuation est. — both on one shared scale so you can read raise-vs-worth at each round directly. Use the toggles to overlay data labels and the niche-peer / market average value lines.

Amount raised · realModeled valuation · estCumulative funded · real
$0$12.5B$25.0B$37.5B$50.0BGrowth/Late · 2018-10-09 Raised $561M (real) Modeled valuation $23.8B (est)$561M$23.8BGrowth/Late2018Growth/Late · 2019-12-09 Raised $55M (real) Modeled valuation $2.3B (est)$55M$2.3BGrowth/Late2019Growth/Late · 2021-06-28 Raised $25M (real) Modeled valuation $792M (est)$25M$792MGrowth/Late2021Growth/Late · 2022-01-18 Raised $12M (real) Modeled valuation $318M (est)$12M$318MGrowth/Late2022Growth/Late · 2022-04-19 Raised $113M (real) Modeled valuation $2.8B (est)$113M$2.8BGrowth/Late2022Growth/Late · 2025-02-24 Raised $75M (real) Modeled valuation $805M (est)$75M$805MGrowth/Late2025+$55M+$25M+$12M+$113M+$75MCumulative $840M

The line shows cumulative reported funding over the period; + labels show new capital added between points when there is room. Toggle on-bar figures, plus the niche-peer and market averages, to read this company against its cohort. Benchmarks are modeled medians.

Financing ladder & sequence gaps
Growth/Late$560.5M · 2018
Growth/Late extension$54.6M · 2019
Growth/Late extension$25.0M · 2021
Growth/Late extension$11.8M · 2022
Growth/Late extension$112.8M · 2022
Growth/Late extension$75.0M · 2025

Stages are modeled from round size (public records carry no series label). No record for: Pre-Seed, Seed, Series A, Series B, Series C, Series D+ — the company may have raised it under a different exemption, merged it into an adjacent record, or skipped it. Sequence completeness: 14%.

Modeled valuation trajectory
$804.8M
Base estimate est.
$468.0M
Conservative case
$973.6M
Upside case
$750.0M
Modeled post-money

Round size and date are reported; the stage label is inferred from round size (latest is Growth/Latea round over $400M). Valuation is modeled from stage benchmarks scaled by the biotech sector profile. Directional, not a quoted figure.

Growth/Late · modeled $23.8B · 2018-10-092018Growth/Late · modeled $2.3B · 2019-12-09Growth/Late · modeled $791.7M · 2021-06-28Growth/Late · modeled $318.2M · 2022-01-18Growth/Late · modeled $2.8B · 2022-04-19Growth/Late · modeled $804.8M · 2025-02-242025
Model inputs · modeled:benchmark-stage-stepup-v1
10%
Dilution assumption
Implied ownership sold in the financing.
72%
Survival probability
62% low · 78% high
1.34×/yr
Annual markup
1.46×/yr upside case
1.4 yr
Elapsed time used
1.4 yr actual, capped for stale marks
biotech
Sector profile
Adjusts growth and survival by industry.
Financing rhythm
15 mo
Avg between rounds
$131.6M/yr
Capital velocity
7.7 yr
On record since
2018
First round
6
Rounds on file
How it compares to the market

Benchmarked against 4293 companies in Biotechnology. Each bar is a median (the middle company, not an average — outliers don't skew it). Two yardsticks: real money raised (reported on Form D) and modeled value (our estimate est.). These are whole-sector medians across all stages, except the per-stage row.

Total raised — vs sector median (real $, all stages) 117× above median
This company$839.8M
Sector median$7.2M
Latest round — vs other Growth/Late rounds in sector (real $, this stage) 0.2× of median
This company$75.0M
Sector median$403.1M
Modeled value — vs sector median (estimate, all stages) 13× above median
This company$804.8M
Sector median$64.2M

Raised more than 100% of sector peers (real $). Modeled value above 87% of peers (estimate).

Niche peers — same stage & era

A tighter cohort than the sector chart above — only companies at the same stage (Growth/Late) that last raised in the same ~3-year era, ranked by modeled value est. (not money raised). This is the exact set the analyst read compares against, so a like-for-like cohort is what makes "over/under-valued" meaningful. This company ranks #5 of 5.

This companyCohort peer
$100.0M$1.0B$10.0B$100.0M$1.0B$10.0BCapital raised (log)Neuralink Corp. · Growth/Late Raised $1.2B · modeled $6.4B (est)Eikon Therapeutics, Inc. · Growth/Late Raised $1.1B · modeled $3.8B (est)Grail, Inc. · Growth/Late Raised $2.2B · modeled $2.9B (est)Treeline Biosciences, Inc. · Growth/Late Raised $1.1B · modeled $1.9B (est)Castle Creek Biosciences, Inc. (this company) Raised $839.8M · modeled $804.8M (est)Castle Creek Biosciences, Inc.
CompanyStageRaised · realValue · estvs peer med.
Neuralink Corp.Growth/Late$1.2B$6.4B2.24×
Eikon Therapeutics, Inc.Growth/Late$1.1B$3.8B1.32×
Grail, Inc.Growth/Late$2.2B$2.9B1.00×
Treeline Biosciences, Inc.Growth/Late$1.1B$1.9B0.65×
Castle Creek Biosciences, Inc. this companyGrowth/Late$839.8M$804.8M0.28×
Full financing history

Stage is inferred from round size est., not reported on the filing — a round's dollar size maps to a bucket: Pre-Seed <$1.0M · Seed $1.0M–$4.0M · Series A $4.0M–$15M · Series B $15M–$40M · Series C $40M–$100M · Series D+ $100M–$400M · Growth/Late >$400M.

StageAmount · realAnnouncedPost-money · estValue · estConf.
Growth/Late$560.5M2018-10-09$5.6B$23.8B90%
Growth/Late$54.6M2019-12-09$546.0M$2.3B90%
Growth/Late$25.0M2021-06-28$250.0M$791.7M90%
Growth/Late$11.8M2022-01-18$118.5M$318.2M90%
Growth/Late$112.8M2022-04-19$1.1B$2.8B90%
Growth/Late$75.0M2025-02-24$750.0M$804.8M90%
What happened at each round

Step-up, pace versus the sector's normal cadence, and revenue/exemption moves — read straight from the reported round facts reported.

  1. Growth/Late$560.5M2018-10-09
    • First recorded raise — entered as Growth/Late.
    • 19 investors on this round.
  2. Growth/Late$54.6M2019-12-09
    • Raised 14 mo later, in step with the ~14 mo sector norm.
    • Round 10.3× smaller than the prior — bridge or down round.
    • 12 investors on this round.
  3. Growth/Late$25.0M2021-06-28
    • Raised 19 mo later, in step with the ~14 mo sector norm.
    • Round 2.2× smaller than the prior — bridge or down round.
    • 36 investors on this round.
  4. Growth/Late$11.8M2022-01-18
    • Came back fast: 7 mo vs the ~14 mo sector norm.
    • Round 2.1× smaller than the prior — bridge or down round.
    • 6 investors on this round.
  5. Growth/Late$112.8M2022-04-19
    • Came back fast: 3 mo vs the ~14 mo sector norm.
    • Round 9.5× larger than the prior — scaling up.
    • 54 investors on this round.
  6. Growth/Late$75.0M2025-02-24
    • Raised again after 34 mo — slower than the ~14 mo sector norm.
    • Round 1.5× smaller than the prior — bridge or down round.
    • 30 investors on this round.
Intelligence
2026 ~Q2
Modeled next raise · ~15mo cadence
$75.0M
Modeled next size est.range $75.0M$120.0M
0.7×
Last step-up
$131.6M/yr
Capital velocity

Predictive signals are modeled est. from this company's own cadence and step-up, plus sector benchmarks — directional, not advice. Peer set and a CSV export live in your analyst workspace.

Key people & operators

Officers, directors and promoters named in this company's public recordsreported — the people who run it (not its investors). "Also runs" counts come from name-matching across all records, so verify before acting.

PersonRoleAlso runsTied since
Antonio Gracias14 other2018-10
Patrick J. Morris7 other2019-12
Antonio J. Gracias6 other2019-12
Jeffrey Aronin5 other2018-10
Patrick Morris5 other2018-10
Michael Derby4 other2018-10
Timothy Cunniff4 other2018-10
Darien Parhad3 other2025-02
Jeffrey S. Aronin3 other2019-12
Timothy M. Cunniff1 other2019-12
W. Bradford Middlekauff1 other2021-06
Babar J. Ghias2022-01
David Brill2025-02
Gregory Bradford Wujek2021-06
Gregory J. MacMichael2021-06
Gregory J. Wujek2019-12
Jude Sullivan2025-02
Mark J. Graf2022-01
Mary Bradford Spellman2021-06
Matthew Crabtree2025-02
Matthew Gantz2025-02
Matthew J. Gantz2021-06
Registry & provenance

Castle Creek Biosciences, Inc. is an official record sourced from the U.S. Securities and Exchange Commission (SEC). U.S. data is aggregated from SEC Form D filings.

United States
Country of record
US
Jurisdiction
1756702
SEC CIK
Similar companies

Nearest neighbours across the whole database — matched on sector, stage and capital scale, and on shared operators (officers or directors named at both companies in public filings). A discovery shortlist, not a valuation cohort — verify before acting, the same way modeled figures are directional.

CompanySectorStageRaised · realValue · estWhy similar
CIRC Biosciences, Inc.BiotechnologySeries B$24.1M$54.7Mnetwork9 shared operators · same sector
Paragon Biosciences Emalex Capital, Inc.PharmaceuticalsSeries D+$376.8M$5.5Bnetwork7 shared operators
Castle Creek Pharmaceuticals, LLCPharmaceuticalsSeries C$48.0M$1.7Bnetwork5 shared operators
Harmony Biosciences II, Inc.PharmaceuticalsSeries D+$345.0M$1.8Bnetwork4 shared operators
Evozyne, Inc.BiotechnologySeries C$144.4M$979.0Mnetwork3 shared operators · same sector
Paragon Biosciences Qlarity Capital, Inc.PharmaceuticalsSeries B$15.0M$510.1Mnetwork3 shared operators
Paragon Biosciences Skyline Capital, LLCPharmaceuticalsSeed$4.0M$150.9Mnetwork3 shared operators
Vaxxinity, Inc.BiotechnologyGrowth/Late$1.4B$928.1Msame sector · same stage
Semantically similar

Matched by meaning, not labels — a local language model reads each company's name, sector and description and ranks the closest in that learned space. This catches look-alikes that cross sector boundaries; the structured list above explains its matches, this one trusts the text. Directional, like every modeled signal here.

CompanySectorStageValue · estMatch
Mill Creek Life Sciences, LLCBiotechnologySeries A$180.8M78%
Castle Biosciences IncBiotechnologySeries A$361.5M78%
Castle Creek Pharmaceuticals, LLCPharmaceuticalsSeries C$1.7B78%
Clear Creek Bio, Inc.BiotechnologySeries A$37.1M77%
Sonoma Biotherapeutics, Inc.BiotechnologySeries D+$7.7B77%
Canopy Biosciences, LLCBiotechnologySeed$92.1M76%
GeneTx Biotherapeutics LLCBiotechnologySeries A$228.6M76%
Shoreline Biosciences, Inc.BiotechnologySeries D+$3.7B76%
Frequently asked
How much funding has Castle Creek Biosciences, Inc. raised?
Castle Creek Biosciences, Inc. has raised approximately $839.8M in disclosed capital across 6 recorded financing rounds, aggregated from public filings.
What is Castle Creek Biosciences, Inc.'s estimated valuation?
Provath's modeled valuation for Castle Creek Biosciences, Inc. is approximately $804.8M (modeled range $468.0M–$973.6M). This is an algorithmic estimate derived from round sizes and same-niche peers — not a quoted or reported figure.
What funding stage is Castle Creek Biosciences, Inc. at?
Castle Creek Biosciences, Inc.'s latest modeled financing stage is Growth/Late. Its most recent recorded round closed around Mon Feb 24.
What does Castle Creek Biosciences, Inc. do and where is it based?
Castle Creek Biosciences, Inc. operates in the Biotechnology sector, based in Exton. Dedicated to making life better for people suffering from rare diseases with few or no treatment options
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